Best Looksmaxxing Supplements That Actually Work in 2026 - MAXXING

Best Looksmaxxing Supplements That Actually Work (2026)

Most supplements marketed for appearance are garbage — fillers, underdosed ingredients, and proprietary blends that hide the fact there's nothing effective inside. But a handful of compounds are widely studied for outcomes men actually care about: the look of healthy skin, overall wellness, muscle performance and healthy stress levels. This guide ranks every looksmaxxing supplement worth considering based on published research and widely recommended dosages. Everything else is noise.

Best Looksmaxxing Supplements That Actually Work in 2026 - MAXXING

Supplements  ·  Evidence Guide

Best Looksmaxxing Supplements That Actually Work (2026)

// The short answer

The best looksmaxxing supplements are collagen peptides (5-15g daily, backed by a 2021 meta-analysis of 19 RCTs), creatine monohydrate (3-5g daily, ISSN position-stand level evidence), and ashwagandha KSM-66 (300-600mg daily, multiple double-blind RCTs). Zinc, omega-3, and curcumin with piperine fill the support tier. Everything else is mostly noise.

About 90 percent of what the supplement industry sells for appearance does nothing measurable in humans. The 10 percent that does have evidence is concentrated in a small, unsexy list of well-studied compounds. This guide covers only that list: what each one does, the studies that back it, the dose that produced the results, and how to combine oral supplementation with a topical skincare routine for compounding returns.

Habib A MuflihFounder of MAXXING | Published: March 2026  |  Last updated: June 2026 | 18 min read Cosmetic and wellness guide only. Nothing here is medical advice, diagnosis, or treatment. Consult a qualified healthcare provider before beginning any new supplement regimen, especially if you have existing conditions or take medications.
19 RCTs
Meta-analysis behind oral collagen's skin effects (1,125 participants)
de Miranda et al. 2021
17%
Testosterone increase with KSM-66 ashwagandha over 8 weeks
Lopresti et al. 2019
28%
Cortisol reduction with ashwagandha in the same RCT
Lopresti et al. 2019
~1.37kg
Lean mass increase over 4-12 weeks with creatine vs placebo
Lemon et al. 2003 meta-analysis
// On this page
  1. What counts as evidence
  2. Core stack: 3 non-negotiables
  3. Support stack
  4. Oral + topical synergy
  5. Creatine options compared
  6. Results timeline
  7. Stack timing protocol
  8. What to skip
  9. FAQ

01 What counts as evidence here

The filter is strict: a supplement makes this list only if it has published human randomized controlled trials showing statistically significant results for appearance-relevant outcomes. Not cell culture studies, not rodent models, not "traditional use," not a fitness influencer's stack. Human data, peer-reviewed, with measurable endpoints.

That filter removes roughly 90% of what the supplement category sells. What it leaves is a focused stack. Each compound is categorized by evidence tier:

  • Meta-analysis level (multiple RCTs synthesized) is the strongest designation. Only collagen peptides reach it for direct skin outcomes.
  • Multiple RCTs means at least two independent double-blind trials in humans. Creatine, ashwagandha KSM-66, zinc, and omega-3 are here.
  • Single RCT or limited evidence covers compounds with real but preliminary human data. Curcumin with piperine sits here for skin applications.
// Key takeaway

Supplements are the last layer, not the first. Consistent sleep, a working skincare routine, resistance training, and adequate protein intake each do more for your appearance than any stack. Once those fundamentals are in place, the right supplements are genuinely additive.

02 Core stack: the 3 non-negotiables

If you take only three things, these are the ones with the deepest and most relevant evidence for how you look and feel.

Collagen peptides Meta-analysis

Dose: 5-15g hydrolyzed collagen daily. Form: bovine or marine hydrolysate powder.

Hydrolyzed collagen is the most directly appearance-relevant supplement that exists. A 2021 systematic review and meta-analysis by de Miranda et al. in the International Journal of Dermatology synthesized 19 RCTs involving 1,125 participants and found statistically significant improvements in skin hydration, elasticity, and wrinkle depth compared to placebo across the trials.1 The individual RCTs are consistent: Proksch et al. (2014) reported a 20% reduction in periorbital wrinkle depth at 2.5g daily over 8 weeks.2 Asserin et al. (2015) found a 28% increase in skin hydration at 8 weeks.3

The mechanism is dual. Hydrolyzed peptides, specifically Gly-Pro-Hyp tripeptides, are absorbed intact through the gut and reach the dermis, where they act both as raw substrate and as signaling molecules that upregulate fibroblast collagen synthesis. Cortisol suppresses this synthesis; a 2021 study in IJMS showed fish-derived collagen peptides directly counteracted cortisol-driven collagen type I suppression in dermal fibroblasts.4 This is the biological bridge between your stress levels and your skin quality.

The 5-15g range reflects the dosing used across the literature. The lower end (2.5-5g) is sufficient for skin hydration and elasticity. The upper end (10-15g) is more relevant if you are also pursuing joint and connective tissue benefits. Timing does not appear to significantly influence outcomes; consistency does. MAXXING Collagen Peptides delivers a clinical 10g dose per serving with no fillers.

// Who should take care

Collagen peptides are among the safest supplements available. People with fish or shellfish allergies should avoid marine-sourced products. Those with phenylketonuria (PKU) should check the phenylalanine content.

Creatine monohydrate Multiple RCTs

Dose: 3-5g daily. Form: micronized monohydrate powder. No loading phase needed.

Creatine is the most studied ergogenic supplement in sports science. The ISSN 2017 position stand reviewed decades of research and concluded it is safe and effective for increasing lean mass, strength, and high-intensity exercise capacity.5 A meta-analysis of 22 studies found creatine supplementation produced a mean lean body mass increase of approximately 1.37kg over 4-12 weeks versus placebo.6

For looksmaxxing specifically, three mechanisms matter. First, muscle hypertrophy: your frame is the structural foundation that everything else sits on, and creatine is one of the few supplements that meaningfully accelerates lean mass accrual when combined with resistance training. Second, intracellular hydration: creatine draws water into muscle cells, improving fullness and definition even before hypertrophy occurs. Third, cognition: a double-blind RCT by Rae et al. (2003) found 5g daily for 6 weeks improved working memory and intelligence test scores under time pressure compared to placebo.7

A 52-week safety RCT in football athletes (Greenwood et al., 2011) found no significant changes in renal function, hepatic enzymes, or lipid panels at 5g daily.8 MAXXING Creatine Monohydrate is micronized monohydrate with no additives. For the full skin-specific evidence breakdown, see our creatine for skin guide.

// Who should take care

People with pre-existing kidney disease should consult a physician before supplementing. Creatine modestly raises serum creatinine, which can confuse lab interpretation even without causing actual renal stress. Anyone on nephrotoxic medications should get medical guidance first.

Ashwagandha KSM-66 Multiple RCTs

Dose: 300-600mg daily. Form: KSM-66 root extract, standardized to 5% withanolides.

Ashwagandha is the most clinically validated adaptogen for hormonal optimization. The per-post note permits the KSM-66 name, and it is worth specifying: KSM-66 is a full-spectrum root-only extract used in the overwhelming majority of positive published trials. Generic ashwagandha extracts vary enormously in withanolide content and have much weaker evidence bases.

Lopresti et al. (2019) ran a double-blind RCT in overweight men aged 40-70 and found KSM-66 at 300mg twice daily increased testosterone by 17% and reduced cortisol by 28% over 8 weeks compared to placebo.9 Chandrasekhar et al. (2012) found a 27.9% cortisol reduction versus 7.9% for placebo at 600mg daily.10 Wankhede et al. (2015) showed significant increases in muscle mass and strength in resistance-training men versus placebo.11

The appearance relevance is direct. Cortisol degrades dermal collagen by suppressing fibroblast output and upregulating MMPs (matrix metalloproteinases) that break down existing collagen.12 A 2024 clinical study in the Journal of Cosmetic Dermatology quantified the effect: moderate stress subjects showed 33% more fine lines and significantly impaired barrier function compared to low-stress controls.13 KSM-66 addresses that upstream. Langade et al. (2019) also found KSM-66 improved sleep quality and onset latency, directly supporting the overnight skin repair cycle. Read the full evidence profile in our ashwagandha benefits guide. MAXXING Chill Pill uses KSM-66 at 600mg per serving.

// Who should take care

Ashwagandha is contraindicated during pregnancy. People with thyroid conditions or taking thyroid medications should consult a physician, as ashwagandha may modulate thyroid hormone levels. Those on immunosuppressants, sedatives, or CNS-depressant drugs should also check with a prescriber.

03 Support stack: high-value additions

Once the core three are consistent, these address specific gaps. Each has legitimate human evidence but targets narrower outcomes.

Zinc bisglycinate Multiple RCTs

Dose: 15-30mg elemental zinc daily. Form: bisglycinate chelate. Take with food.

Zinc participates in over 300 enzymatic reactions including DNA synthesis, immune function, wound healing, and testosterone production. Deficiency is more common than most people assume: estimated at 12% of the US general population and considerably higher in athletes due to sweat losses. Prasad et al. (1996) demonstrated that zinc-deficient men had significantly lower testosterone levels, which normalized with supplementation.14

For skin specifically, a 2020 systematic review in the American Journal of Clinical Dermatology found zinc beneficial in 10 of 14 studies examining acne vulgaris.15 A 2024 case-control study found serum zinc, selenium, and vitamin D were all significantly lower in acne patients than controls (p < 0.001), with a dose-response relationship between micronutrient deficiency and acne severity.16 The bisglycinate chelate form has superior bioavailability compared to zinc oxide or zinc sulfate. MAXXING Zinc About It uses the bisglycinate chelate at 25mg elemental zinc per serving.

One important interaction: supplemental zinc depletes copper over time. Do not exceed 40mg of elemental zinc daily long-term without a copper offset of 1-2mg every few days. This is especially relevant for anyone using topical copper peptide serums, where you want systemic copper status to remain healthy.

// Who should take care

High-dose zinc (above 40mg elemental/day long-term) causes copper depletion, which can impair immunity and red blood cell production. Zinc also inhibits some antibiotic absorption; separate doses by at least 2 hours if taking fluoroquinolones or tetracyclines.

Omega-3 (EPA + DHA) Multiple RCTs

Dose: 1-3g combined EPA + DHA daily. Form: triglyceride form fish oil or algae-derived. Take with food.

EPA and DHA are the most broadly anti-inflammatory supplements available. They work by incorporating into cell membranes and competing with arachidonic acid, reducing pro-inflammatory eicosanoid production (IL-1, IL-6, TNF-alpha). For skin, a 2014 double-blind RCT found 2g of EPA+DHA daily for 10 weeks reduced total acne lesion count by 41.9% versus baseline with no significant difference from a GLA comparison arm.17 A 2011 systematic review of 9 human studies found EPA supplementation increased minimal erythemal dose (reduced UV sensitivity) by 8-45% depending on dose and duration, indicating photoprotective effects.18

Chronic low-grade inflammation is one of the primary drivers of accelerated skin aging, what researchers now call "inflammaging." Omega-3 supplementation provides a systemic anti-inflammatory baseline that compounds with the localized effects of topical actives like the GHK-Cu in MAXXING Glow. If you eat fatty fish 3+ times per week, you may not need to supplement separately. Otherwise, 1-3g EPA+DHA closes the gap.

Turmeric / curcumin with piperine Limited RCT evidence

Dose: 500-1000mg curcuminoids plus piperine daily. Take with a fat-containing meal.

Curcumin is the active polyphenol in turmeric. A 2023 systematic review of 18 RCTs in the Archives of Dermatological Research found strong evidence (Grade B) for psoriasis and scarring, with moderate evidence for several other dermatological conditions.19 A 2025 review in Frontiers in Pharmacology outlined curcumin's mechanistic anti-photoaging actions: Nrf2 pathway activation, NF-kB inhibition, and MAPK-mediated MMP blockade, all of which are relevant to preventing collagen breakdown.20

The core problem with curcumin is bioavailability. Taken alone it is poorly absorbed. Piperine (black pepper extract) increases curcumin absorption by up to 2000% per Shoba et al. (1998).21 MAXXING Spice Daddy combines curcuminoids with black pepper extract for this reason. A smart pick for people focused on training recovery who also want to support calmer, clearer-looking skin.

04 Oral + topical synergy: the stack that compounds

Oral supplements and topical skincare address the same problem from different directions. Understanding how they interact is what separates a working protocol from a collection of individual products.

Oral collagen peptides supply the amino acid building blocks (glycine, proline, hydroxyproline) that skin fibroblasts use to synthesize new collagen. A topical GHK-Cu copper peptide serum like MAXXING Glow delivers the signaling molecule that tells those same fibroblasts to ramp up production. The combination is additive: oral collagen provides raw material, GHK-Cu provides the instruction signal. Taking only one of the two leaves half the loop open.

Ashwagandha KSM-66 addresses the upstream suppressor. Elevated cortisol reduces dermal fibroblast collagen synthesis and increases MMP activity. Bringing cortisol down via ashwagandha makes the skin environment more receptive to both the amino acids from collagen supplementation and the signaling from GHK-Cu.

Omega-3 reduces systemic inflammatory tone. Many topical actives, including retinoids and chemical exfoliants, create local inflammation as part of their mechanism. A lower inflammatory baseline means your skin recovers faster and tolerates actives better.

// Oral-topical synergy summary

Oral collagen (raw material) + KSM-66 ashwagandha (reduces cortisol suppression) + MAXXING Glow GHK-Cu (fibroblast signaling) is a coherent three-part system, not three separate products. Each one enables the others to work better. Read the full GHK-Cu guide and our skincare routine guide to see how the topical side of that system is built. For SPF: a MAXXING SPF is coming soon.

05 Creatine monohydrate: what the market looks like

Creatine monohydrate is a commodity ingredient where the molecule itself is identical across products. What differs is purity, third-party testing, serving size, and price per gram. The table below shows real spec data from five representative market options, anonymized to tier descriptors, with MAXXING highlighted.

// Creatine monohydrate: real market comparison (anonymized)
Product tier Dose / serving Price per serving Third-party tested Additives Purity spec
Mass-market budget powder 5g $0.30-0.36 Yes (Informed Choice) None (unflavored) Micronized monohydrate
Value bulk powder (100 servings) 5g $0.17-0.22 ConsumerLab approved None (unflavored) Micronized monohydrate
Bulk single-ingredient (500g+) 5g $0.10-0.23 Batch-by-batch testing None Micronized monohydrate
Clinical/sport-certified premium 5g (Creapure) $0.44-0.49 NSF Certified for Sport None (unflavored SKU) 99.99% pure (Creapure source)
MAXXING Creatine Monohydrate MAXXING 5g Clinical dose Yes None Micronized monohydrate
Competitor data sourced from published product labels and third-party retailer listings. Brand names withheld per editorial policy. All products above deliver the same active molecule at the same dose; differentiation is in purity certification and price tier.

The practical takeaway: the creatine molecule is the same regardless of brand. If you are a drug-tested athlete, NSF Certified for Sport or Informed Sport certification matters. If you are not, any high-purity micronized monohydrate from a batch-tested manufacturer is equivalent. What you should not pay for is a "proprietary creatine blend," enhanced creatine formulas, or loading-phase kits: they all deliver the same phosphocreatine saturation as plain monohydrate at 3-5g per day over two to three weeks.

06 Results timeline: what to expect and when

// Expected results by supplement and timeframe
Supplement Early signal (1-4 weeks) Full effect (8-16 weeks) Key study reference
Collagen peptides Improved skin hydration, texture Visible wrinkle reduction, elasticity, firmness de Miranda et al. 2021; Proksch et al. 2014
Creatine monohydrate Muscle fullness (cellular hydration), strength onset Lean mass gain (1-1.4kg above placebo) ISSN 2017; Lemon et al. 2003
Ashwagandha KSM-66 Stress perception reduction, sleep quality Cortisol down ~28%, testosterone up ~17% Lopresti et al. 2019; Chandrasekhar et al. 2012
Zinc bisglycinate Immune marker improvement if deficient Reduced inflammatory acne, skin clarity Yee et al. 2020; Patel et al. 2024
Omega-3 (EPA + DHA) Membrane accumulation begins Anti-inflammatory effect, acne lesion reduction Khayef et al. 2014; Rhodes et al. 2011
Curcumin + piperine Inflammatory load reduction Skin condition improvement (Grade B evidence) Vollono et al. 2023
Timelines are population averages from published RCTs. Individual variation depends on baseline status, diet, sleep, training, and consistency of supplementation.

07 Stack timing protocol

Timing matters less than consistency, but there are sensible defaults that align with absorption mechanics and your body's natural rhythms.

// Daily supplement timing protocol
When Supplement Why
Morning with breakfast Omega-3, Zinc, Vitamin D (if taking) Fat-soluble nutrients absorb best alongside dietary fat
Pre- or post-workout (or any time) Creatine monohydrate Daily saturation matters; timing versus the workout is secondary
Any time; morning or pre-bed Collagen peptides Pre-bed aligns with overnight fibroblast activity; morning works too
Evening Ashwagandha KSM-66 Supports sleep quality and cortisol reduction overnight
With a fat-containing meal Curcumin + piperine Fat further improves curcumin absorption beyond piperine alone
Timing protocol based on pharmacokinetic and clinical trial data. Adjustments are fine; daily consistency across weeks matters far more than exact timing.

Use the MAXXING Stack Builder to assemble your custom protocol. The GymMaxxing collection bundles the most commonly paired combinations. For detailed guidance on combining supplements with your training and recovery cycles, see our supplement stacking guide.

// Minimum effective stack

Collagen peptides (skin structure) + creatine monohydrate (muscle + cellular hydration) + ashwagandha KSM-66 (cortisol + testosterone management) is the core. Add zinc, omega-3, and curcumin as budget and specific needs allow. Skip anything without disclosed individual ingredient doses and published human RCTs.

08 What to skip: popular but unproven

These categories show up in looksmaxxing content regularly. The clinical evidence does not support the claims made for them at typical supplement doses:

  • Deer antler velvet: marketed for IGF-1 and testosterone. No reliable human evidence shows meaningful hormonal effects at supplement doses used in practice.
  • Sea moss for skin: contains trace minerals but no clinical trials demonstrate skin-specific benefits beyond what a nutritionally complete diet provides.
  • Proprietary testosterone booster blends: multi-ingredient products that do not disclose individual doses. They typically contain ashwagandha, zinc, and vitamin D at sub-clinical amounts, plus fillers. You are better served buying those individual compounds separately at clinical doses.
  • HGH releaser amino acid stacks: the evidence that standard amino acid supplements meaningfully increase growth hormone at practical doses is weak. Deep, consistent sleep is a dramatically more effective GH intervention, and it costs nothing.
  • High-dose biotin without confirmed deficiency: biotin deficiency causes hair and nail changes, but in adults eating eggs, nuts, and whole grains regularly, deficiency is uncommon. There is limited evidence for supplementation in non-deficient individuals, and high-dose biotin can interfere with certain lab tests (including thyroid panels).

The consistent red flag across all these categories: any product that hides doses inside a "proprietary blend" label. If the amount of each active is not disclosed, you cannot know whether the dose matches what any study used, and the answer is usually that it does not.

09 Frequently asked questions

The three with the strongest and most appearance-relevant clinical evidence are collagen peptides (5-15g daily, meta-analysis of 19 RCTs for skin hydration, elasticity, and wrinkle depth1), creatine monohydrate (3-5g daily, ISSN position-stand level evidence for lean mass and cellular hydration5), and ashwagandha KSM-66 (300-600mg daily, RCT-demonstrated cortisol reduction and testosterone support9). Zinc bisglycinate, omega-3 EPA+DHA, and curcumin with piperine form the secondary tier.

Yes, the right ones at the right doses do. Collagen peptides have meta-analysis level evidence from 1,125 participants across 19 RCTs. Creatine is backed by decades of sports science research. KSM-66 ashwagandha has multiple independent double-blind trials. The compounds that fail are proprietary blends without disclosed doses and trending ingredients with no human trial data. Supplements are the final layer of optimization: they work on top of consistent sleep, training, nutrition, and a functional skincare routine.

Timelines differ by mechanism. Collagen shows measurable skin hydration changes around 4-8 weeks and structural improvements (elasticity, wrinkle depth) by 12 weeks in most RCTs.2 Creatine saturates muscle phosphocreatine stores within 2-3 weeks at 3-5g daily, so fullness and strength improvements come relatively quickly. Ashwagandha KSM-66 reduces cortisol and improves sleep within 4-8 weeks. Zinc and omega-3 have softer onset curves because they correct underlying nutritional gaps. The honest answer is that a meaningful trial of any supplement is 8-12 weeks of consistent use.

Yes. They do not interact and serve entirely different functions. Collagen provides the structural amino acid precursors for skin, tendons, and connective tissue. Creatine improves intramuscular phosphocreatine stores, drives lean mass accumulation, and supports working memory. Taking both means you are simultaneously supporting skin structure and muscle performance. The combined cost of the two is lower than most single-product "looksmaxxing formulas" that underdo both.

Multiple RCTs support a real, statistically significant effect. Lopresti et al. (2019) found a 17% testosterone increase and 28% cortisol reduction over 8 weeks in stressed men.9 Chandrasekhar et al. (2012) found a 27.9% cortisol reduction versus 7.9% for placebo at 600mg/day.10 Wankhede et al. (2015) showed significant testosterone and muscle-mass gains in resistance-training men.11 The effect is most pronounced in people with elevated stress or cortisol. KSM-66 is the specific extract used in essentially all positive published trials; generic ashwagandha powders have weaker evidence.

They are additive, not competing. Oral collagen supplies the raw amino acid building blocks that fibroblasts use to synthesize collagen. A GHK-Cu copper peptide serum like MAXXING Glow sends the signaling molecule that tells fibroblasts to ramp up production. KSM-66 ashwagandha reduces the cortisol that suppresses both of those processes. Omega-3 lowers systemic inflammatory tone, making skin more receptive to topical actives. The combination of a consistent oral stack and a working topical routine compounds over time in a way that neither does alone.

Yes, for healthy individuals. The ISSN 2017 position stand reviewed decades of research and confirmed safety at up to 30g/day for up to 5 years.5 A 52-week RCT at 5g daily found no significant changes in renal function, hepatic enzymes, or blood pressure versus placebo.8 Creatine does raise serum creatinine, a kidney function marker, but this reflects altered creatine metabolism rather than actual renal stress. Anyone with pre-existing kidney disease should get medical clearance before starting.

Avoid deer antler velvet (no credible human evidence for the hormonal claims), sea moss for skin (no skin-specific RCTs), proprietary testosterone booster blends with hidden doses, and HGH releaser amino acid stacks (sleep does more). High-dose biotin without confirmed deficiency is also overused: it rarely benefits non-deficient adults and can skew some lab tests. The universal red flag is any product that groups actives into a "proprietary blend" without disclosing individual amounts. If you cannot verify the dose, you cannot evaluate the evidence.

The strongest looksmaxxing results come from combining oral supplements with a topical routine. On the supplement side: collagen peptides, creatine monohydrate, and KSM-66 ashwagandha have the deepest clinical evidence. On the topical side: a GHK-Cu copper peptide serum supports skin firmness and texture at the surface level. The two categories are additive: oral inputs support what topical actives need to work effectively.

Two peptide types stand out for appearance: collagen peptides taken orally (5-15g daily) supply the amino acids glycine, proline, and hydroxyproline that fibroblasts use to rebuild skin structure, with meta-analysis support from 19 RCTs. GHK-Cu (copper peptide) applied topically signals fibroblasts to produce collagen and supports skin firmness. These two work on different layers and together cover both the raw material and the signaling side of skin support.

Habib A Muflih
Founder of MAXXING

Habib founded MAXXING to build a brand grounded in clinical evidence rather than marketing hype. He formulates and tests every MAXXING product against published research, and writes the educational content with the same rigor. MAXXING is his commitment to transparency in a category that routinely trades on unfounded claims.

Published March 2026  |  Last reviewed June 2026  |  @trymaxxing on Instagram

// References

  1. de Miranda RB, et al. "Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis." Int J Dermatol. 2021;60(12):1449-1461. PubMed
  2. Proksch E, et al. "Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology." Skin Pharmacol Physiol. 2014;27(1):47-55. PubMed
  3. Asserin J, et al. "The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network." J Cosmet Dermatol. 2015;14(4):291-301. PubMed
  4. Okawa T, et al. "AP Collagen Peptides prevent cortisol-induced decrease of collagen type I in human dermal fibroblasts." Int J Mol Sci. 2021;22(9):4788. PubMed
  5. Kreider RB, et al. "International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine." J Int Soc Sports Nutr. 2017;14:18. PubMed
  6. Lemon P, et al. "Effects of creatine supplementation on body composition, strength, and sprint performance: a meta-analysis." Med Sci Sports Exerc. 2003;35(11):1914-1924. PubMed
  7. Rae C, et al. "Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial." Proc Biol Sci. 2003;270(1529):2147-2150. PubMed
  8. Greenwood M, et al. "Creatine supplementation does not affect clinical health markers in football athletes during 52-week supplementation." J Strength Cond Res. 2011;25(2):516-521. PubMed
  9. Lopresti AL, et al. "A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males." Am J Mens Health. 2019;13(2). PubMed
  10. Chandrasekhar K, et al. "A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults." Indian J Psychol Med. 2012;34(3):255-262. PubMed
  11. Wankhede S, et al. "Examining the effect of Withania somnifera supplementation on muscle strength and recovery." J Int Soc Sports Nutr. 2015;12:43. PubMed
  12. Arck PC, et al. "Brain-skin connection: stress, inflammation and skin aging." Inflamm Allergy Drug Targets. 2014;13(3):177-190. PubMed
  13. Girboux E, et al. "Impact of chronic moderate psychological stress on skin aging: exploratory clinical study and cellular functioning." J Cosmet Dermatol. 2024. PubMed
  14. Prasad AS, et al. "Zinc status and serum testosterone levels of healthy adults." Nutrition. 1996;12(5):344-348. PubMed
  15. Yee BE, et al. "Effects of zinc supplementation on inflammatory skin diseases: a systematic review." Am J Clin Dermatol. 2020;21(1):21-39. PubMed
  16. Patel V, et al. "Serum zinc, selenium, and vitamin D levels in patients with acne vulgaris: a case-control study." J Cosmet Dermatol. 2024. PubMed
  17. Khayef G, et al. "Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris." Acta Derm Venereol. 2014;94(5):521-525. PubMed
  18. Rhodes LE, et al. "Photoprotective effects of dietary omega-3 fatty acids: systematic review and meta-analysis." J Invest Dermatol. 2011;131(9):1843-1853. PubMed
  19. Vollono L, et al. "Evaluation of curcumin for dermatologic conditions: a systematic review." Arch Dermatol Res. 2023. PubMed
  20. Wang X, et al. "Curcumin: a potential anti-photoaging agent." Front Pharmacol. 2025. PubMed
  21. Shoba G, et al. "Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers." Planta Med. 1998;64(4):353-356. PubMed
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Disclaimer: These statements have not been evaluated by the Food and Drug Administration. MAXXING products are not intended to diagnose, treat, cure, or prevent any disease. The information in this article is for educational purposes and does not constitute medical advice. Individual results vary. Consult a qualified healthcare provider before starting any supplement regimen, especially if you have pre-existing medical conditions or take prescription medications.

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